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Pyrophosphate¿Í hydroxyapatite ¹× vitamin-E ¹èÇÕ¼¼Ä¡Á¦(ÛÕùêá©öÍð¥) Ä¡Àú¿°¿ÏÈ­È¿°ú(öÍîÒæúèÐûúüùÍý)¿Í Ä¡¼®Çü¼º¾ïÁ¦È¿°ú(öÍà´û¡à÷åäð¤üùÍý)¿¡ °ü(μ) ¿¬±¸(æÚϼ)

A clinical study of toothpaste containing pyrophosphate, hydroxyapatite and Vitamin-E on the prevention of calculus formation and gingivitis.

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Abstract

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ÀúÀÚµéÀº, 3.5% tetra sodium pyrophoshate¿Í 0.5% hydroxyapatite ¹× 0.1% vitamin-E¸¦
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±âÇÑ ¼ººÐÀ» Á¦¿ÜÇÏ°í´Â ¸ðµç ¼ººÐÀÌ µ¿ÀÏÇÑ ´ëÁ¶¼¼Ä¡Á¦·Î 12ÁÖ°£ ÀÕ¼ÖÁúÇÏ°Ô ÇÑ ÈÄ, ÀÕ¼Ö
Áú ±â°£ 4ÁÖ¿Í 12ÁÖ¿¡ °¢°¢ Ä¡ÀºÁö¼ö¿Í Ä¡¼®Áö¼ö¸¦ ÃøÁ¤ÇÏ¿©, ½ÇÇè½ÃÀÛÀü°ú °æ°í±â°£¿¡ µû
¸¥ Ä¡Àº¿°¿ÏÈ­È¿°ú¿Í Ä¡¼®Çü¼º¾ïÁ¦È¿°ú¸¦ »êÃâ ºñ±³ °ËÅäÇÑ °á°ú, ´ÙÀ½°ú °°Àº °á·ÐÀ» ¾ò¾ú
´Ù.
1. 3.5% teuasodium pyrophoshate¿Í 0.5% hydroxyapatite ¹× 0.1% vitamin-E¸¦ ¹èÇÕÇÑ
¼¼Ä¡Á¦·Î 12ÁÖ°£ ÀÕ¼ÖÁúÇÑ °á°ú Åë°èÀûÀ¸·Î À¯ÀÇÇÑ Ä¡Àº¿°°¨¼ÒÈ¿°ú°¡ ÀÎÁ¤µÇ¾ú´Ù(P<0.05).
2. 3.5% tetra sodium pyrophoshate¿Í 0.5% hydroxyapatite ¹× 0.1% vitamin-E¸¦ ¹èÇÕÇÑ
¼¼Ä¡Á¦·Î 12ÁÖ°£ ÀÕ¼ÖÁúÇÑ °á°ú Åë°èÀûÀ¸·Î À¯ÀÇÇÑ Ä¡¼®Çü¼º¾ïÁ¦È¿°ú°¡ ÀÎÁ¤µÇ¾ú´Ù
(P<0.05).

80 subjects completed a 3month, double blind clinical study which examine the effects
of a 3.5% tetrasodium pyrophosphate/ 0.5% hydroxyapatite on the prevention of calculus
formation and gingivitis. Control dentifrice had the same formulation with experimental
dentifrice exept it did not contain pyrophosphate/hydroxyapatie.
The subjects were divided by experimental and control group and received an oral
prophylaxis on six lower anterior teeth. After an oral prophylaxis, experimental and
control dentifrices were given to subjects according to assigned groups and assigned to
use these dentifrices for the next 3 months.
Calculus index was checked on 6 lower anterior teeth surfaces and Gingival Index
was checked on all gingiva except 6 lower anterior teeth. Calculus index and Gingival
index were scored 5 times: before an oral prophylaxis, after 4 and 12 weeks of use of
each dentifrice. Modified Volpe-Manhold calculus index and Gingival index of L e &
Silness were used to score each index.
The obtained results were as follows;
1 3.5% tetrasodium pyrophosphate/ 0.5% hydroxyapatite dentifrice was shown to
provide a statistically significant reduction of gingivitis after 12 weeks(P<0.05).
2. 3.5% tetrasodium pyrophosphate/ 0.5% hydroxyapatite dentifrice was shown to
provide a statistically significant reduction of calculus formation after 12 weeks(P<0.05).

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